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Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2015

Cameron Garth, Pellicci Daniel G, Uldrich Adam P, Besra Gurdyal S, Illarionov Petr, Williams Spencer J, La Gruta Nicole L, Rossjohn Jamie, Godfrey Dale I

Abstract excerpt

NKT cells recognize lipid-based Ags presented by CD1d. Type I NKT cells are often referred to as invariant owing to their mostly invariant TCR α-chain usage (Vα14-Jα18 in mice, Vα24-Jα18 in humans). However, these cells have diverse TCR β-chains, including Vβ8, Vβ7, and Vβ2 in mice and Vβ11 in humans, joined to a range of TCR Dβ and Jβ genes. In this study, we demonstrate that TCR β-chain composition can...

Topics

Animals
Antigens, CD1d
Genes, T-Cell Receptor beta
Genetic Variation
Globosides
Glucosylceramides
Humans
Lipids
Lymphocyte Activation
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Natural Killer T-Cells

Receptors, Antigen, T-Cell, alpha-beta

Trihexosylceramides

Source

Identifiers

PMID: 26423148
DOI: 10.4049/jimmunol.1501222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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