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Article

A method for inferring the rate of occurrence and fitness effects of advantageous mutations.

Genetics - 1 Dec 2011

Schneider Adrian, Charlesworth Brian, Eyre-Walker Adam, Keightley Peter D

Abstract excerpt

The distribution of fitness effects (DFE) of new mutations is of fundamental importance in evolutionary genetics. Recently, methods have been developed for inferring the DFE that use information from the allele frequency distributions of putatively neutral and selected nucleotide polymorphic variants in a population sample. Here, we extend an existing maximum-likelihood method that estimates the DFE under the...

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Identifiers

PMID: 21954160
DOI: 10.1534/genetics.111.131730
PMCID: PMC3241409

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Source receipt: pubmed, retrieved 7 Sept 2026.

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