Article
polyDFE: Inferring the Distribution of Fitness Effects and Properties of Beneficial Mutations from Polymorphism Data.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Tataru Paula, Bataillon Thomas
Abstract excerpt
The possible evolutionary trajectories a population can follow is determined by the fitness effects of new mutations. Their relative frequencies are best specified through a distribution of fitness effects (DFE) that spans deleterious, neutral, and beneficial mutations. As such, the DFE is key to several aspects of the evolution of a population, and particularly the rate of adaptive molecular evolution (α)....
Topics
- Algorithms
- Animals
- Computational Biology
- Evolution, Molecular
- Genetic Fitness
- Mutation
- Pan troglodytes
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA