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polyDFE: Inferring the Distribution of Fitness Effects and Properties of Beneficial Mutations from Polymorphism Data.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Tataru Paula, Bataillon Thomas

Abstract excerpt

The possible evolutionary trajectories a population can follow is determined by the fitness effects of new mutations. Their relative frequencies are best specified through a distribution of fitness effects (DFE) that spans deleterious, neutral, and beneficial mutations. As such, the DFE is key to several aspects of the evolution of a population, and particularly the rate of adaptive molecular evolution (α)....

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PMID: 31975166
DOI: 10.1007/978-1-0716-0199-0_6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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