Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2003

Piganeau Gwenaël, Eyre-Walker Adam

Abstract excerpt

We present a method for estimating the distribution of fitness effects of new amino acid mutations when those mutations can be assumed to be slightly advantageous, slightly deleterious, or strongly deleterious. We apply the method to mitochondrial data from several different species. In the majority of the data sets, the shape of the distribution is approximately exponential. Our results provide an estimate of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 12925735
DOI: 10.1073/pnas.1833064100
PMCID: PMC193562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock.PMID 12925735Read ↗

The distribution of fitness effects of new mutations.Semantic proximity Read ↗

What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?Semantic proximity Read ↗

Effects of new mutations on fitness: insights from models and data.Semantic proximity Read ↗

The distribution of fitness effects of new deleterious amino acid mutations in humans.Semantic proximity Read ↗

The relation between the neutrality index for mitochondrial genes and the distribution of mutational effects on fitness.Semantic proximity Read ↗

A method for inferring the rate of occurrence and fitness effects of advantageous mutations.Semantic proximity Read ↗

Inferring the distributions of fitness effects and proportions of strongly deleterious mutations.Semantic proximity Read ↗

Inferring Parameters of the Distribution of Fitness Effects of New Mutations When Beneficial Mutations Are Strongly Advantageous and Rare.Semantic proximity Read ↗

Estimating the proportion of beneficial mutations that are not adaptive in mammals.Semantic proximity Read ↗

What does the distribution of fitness effects of new mutations reflect? Insights from plants.Semantic proximity Read ↗

The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals.Semantic proximity Read ↗

Inferring the distribution of mutational effects on fitness in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.