Article
Effects of new mutations on fitness: insights from models and data.
Annals of the New York Academy of Sciences - 1 Jul 2014
Bataillon Thomas, Bailey Susan F
Abstract excerpt
The rates and properties of new mutations affecting fitness have implications for a number of outstanding questions in evolutionary biology. Obtaining estimates of mutation rates and effects has historically been challenging, and little theory has been available for predicting the distribution of fitness effects (DFE); however, there have been recent advances on both fronts. Extreme-value theory predicts the DFE...
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