Article
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.
Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2011
Beirowski Bogdan, Gustin Jason, Armour Sean M, Yamamoto Hiroyasu, Viader Andreu, North Brian J, Michán Shaday, Baloh Robert H, Golden Judy P, Schmidt Robert E, Sinclair David A, Auwerx Johan, Milbrandt Jeffrey
Abstract excerpt
The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination. Here, we show that Sirt2 expression in SCs is correlated with that of structural myelin components...
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