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SIRT1-based therapy targets a gene program involved in mitochondrial turnover in a model of retinal neurodegeneration

19 Apr 2025

Abstract excerpt

Neurodegenerative diseases of the eye such as optic neuritis (ON) are hallmarked by retinal ganglion cell (RGC) loss and optic nerve degeneration leading to irreversible blindness. Therapeutic interventions enhancing expression or activity of SIRT1, an NAD + -dependent deacetylase, support, at least in part, survival of RGCs in the face of injury. Herein, we used mice with experimental autoimmune...

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PMID: 40253451
DOI: 10.1038/s41598-025-97456-8

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