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The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

26 Jul 2011

Abstract excerpt

Sirtuin 2 (SIRT2) is one of seven known mammalian protein deacetylases homologous to the yeast master lifespan regulator Sir2. In recent years, the sirtuin protein deacetylases have emerged as candidate therapeutic targets for many human diseases, including metabolic and age-dependent neurological disorders. In non-neuronal cells, SIRT2 has been shown to function as a tubulin deacetylase and a key regulator of...

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PMID: 21791548
DOI: 10.1093/hmg/ddr326

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