Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.

Cell reports - 28 Mar 2017

Chen Qiang, Hao Wenhui, Xiao Cuiying, Wang Ruihong, Xu Xiaoling, Lu Huiyan, Chen Weiping, Deng Chu-Xia

Abstract excerpt

Preadipocytes initiate differentiation into adipocytes through a cascade of events. Mitotic clonal expansion, as one of the earliest events, is essential for adipogenesis. However, the underlying mechanisms that regulate mitotic clonal expansion remain elusive. SIRT6 is a member of the evolutionarily conserved sirtuin family of nicotinamide adenine dinucleotide (NAD)+-dependent protein deacetylases. Here, we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adipocytes
Share to Adipogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Casein Kinase II

Share to Clone Cells

Share to Kinesins

Share to Mitosis

Share to Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 28355567
DOI: 10.1016/j.celrep.2017.03.006
PMCID: PMC9396928

Genes

SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.PMID 28355567Read ↗

Epigenomics Analysis of the Suppression Role of SIRT1 via H3K9 Deacetylation in Preadipocyte DifferentiationSemantic proximity Read ↗

Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant.Semantic proximity Read ↗

A Novel Negative Regulator of Adipogenesis: MicroRNA-363Semantic proximity Read ↗

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.Semantic proximity Read ↗

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasisSemantic proximity Read ↗

Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancerSemantic proximity Read ↗

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in miceSemantic proximity Read ↗

The functional role of Higd1a in mitochondrial homeostasis and in multiple disease processesSemantic proximity Read ↗

The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesisSemantic proximity Read ↗

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.Semantic proximity Read ↗

VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigeneticsSemantic proximity Read ↗

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5 in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.