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Article

Nab proteins are essential for peripheral nervous system myelination.

Nature neuroscience - 1 Jul 2005

Le Nam, Nagarajan Rakesh, Wang James Y T, Svaren John, LaPash Christine, Araki Toshiyuki, Schmidt Robert E, Milbrandt Jeffrey

Abstract excerpt

Mutations that disrupt Egr2 transcriptional activity cause severe demyelinating peripheral neuropathies. Here we provide evidence that Nab1 and Nab2 proteins are critical transcriptional modulators of Egr2 in myelinating Schwann cells. Like Egr2, these proteins are essential for Schwann cell differentiation into the myelinating state. Mice lacking both Nab1 and Nab2 show severe congenital hypomyelination of...

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Identifiers

PMID: 16136673
DOI: 10.1038/nn1490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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