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Article

Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation

25 Apr 2019

Abstract excerpt

We have previously found that Sirt2 enhanced the outgrowth of cellular processes and MBP expression in CG4 cells, where Sirt2 expression is suppressed by transcription factor Nkx2.2. However, the detailed mechanism of Sirt2 facilitating oligodendroglial cell differentiation remained unclear. In the present study, we observed that Sirt2 partially translocated into the nuclei when CG4 cells were induced to...

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PMID: 31020898
DOI: 10.1080/15384101.2019.1609818

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