Article
Adrenal-specific transgene expression and derivation of conditionally immortal rat adrenocortical cell lines.
Endocrine research - 1 Jan 2000
Morley S D, Viard I, Parker K L, Mullins J J
Abstract excerpt
Conditional immortalisation of cells is a powerful tool for establishing in vitro models maintaining a differentiated phenotype. We are utilising this approach to derive cell lines that maintain the characteristics of glomerulosa and fasciculata cells of the adrenal cortex. Such cell lines should provide a system in which to study aspects of adrenocortical function that are relevant to hypertension, such as the...
Topics
- Adrenal Cortex
- Animals
- Animals, Genetically Modified
- Antigens, Viral
- Cell Differentiation
- Cell Line
- Cell Survival
- Gene Expression
- Mice
- Mice, Transgenic
- Organ Specificity