Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered post-translational processing of p21ras oncoprotein in a transformation-suppressed cell line.

Oncogene - 1 Jul 1991

Huang S, Axelrod D E

Abstract excerpt

We have isolated a transformation-suppressed cell line, R35, which is altered in the maturation of p21ras. It was obtained from the transformed cell line NIH3T3(rasEJ) as a revertant with flat morphology and anchorage dependent growth. Immunoprecipitation of steady state labeled ras proteins reve...

Topics

Animals
Cell Fractionation
Cell Line, Transformed
Cell Membrane
Cytoplasm
Electrophoresis, Polyacrylamide Gel
Immunosorbent Techniques
Methionine
Methylation
Mice
Molecular Weight
Mutation
Palmitic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Palmitic Acids

Polyisoprenyl Phosphates

Protein Precursors

Protein Processing, Post-Translational

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 1861867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1861867-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered post-translational processing of p21ras oncoprotein in a transformation-suppressed cell line.PMID 1861867Read ↗

Characterization of recessive (mediator-) revertants from NIH 3T3 cells transformed with a c-H-ras oncogene.Semantic proximity Read ↗

The p21 ras C-terminus is required for transformation and membrane association.Semantic proximity Read ↗

Development of an in vitro model of tumor progression using v-raf and v-raf/v-myc transformed rat liver epithelial cells: correlation of tumorigenicity with the downregulation of specific proteins.Semantic proximity Read ↗

Increased tyrosine phosphorylation in ras transformed fibroblasts occurs prior to manifestation of the transformed phenotype.Semantic proximity Read ↗

Requirement of estrogen receptor expression and function for [12Val] K-Ras-mediated NIH3T3 cell transformation.Semantic proximity Read ↗

V-K-ras transformation induces reversion to an earlier developmental form in adult rat adrenal cells.Semantic proximity Read ↗

Novel revertants of H-ras oncogene-transformed R6-PKC3 cells.Semantic proximity Read ↗

Cellular ras gene activity is required for full neoplastic transformation by polyomavirus.Semantic proximity Read ↗

Stability of p53 protein in rat cells transformed by various viral transforming genes.Semantic proximity Read ↗

Transformation-defective polyoma middle T antigen mutants defective in PLCgamma, PI-3, or src kinase activation enhance ERK2 activation and promote retinoic acid-induced, cell differentiation like wild-type middle T.Semantic proximity Read ↗

Altered glycosylation in Madin-Darby canine kidney (MDCK) cells after transformation by murine sarcoma virus.Semantic proximity Read ↗

Phosphatidylinositol-3-OH kinase as a direct target of Ras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.