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Article

In vitro culture on Matrigel favors the long-term maintenance of rat zona glomerulosa-cell differentiated phenotype.

International journal of molecular medicine - 1 Jun 2006

Spinazzi Raffaella, Petrelli Lucia, Guidolin Diego, Carraro Gianni, Casale Valentina, Tortorella Cinzia, Neri Giuliano, Albertin Giovanna, Andreis Paola G, Nussdorfer Gastone G

Abstract excerpt

Zona glomerulosa (ZG) cells cultured on plastic within few days dedifferentiate losing their capacity to secrete aldosterone (ALDO) in appreciable amounts. Evidence indicates that extracellular matrix modulates the secretory behavior of adrenocortical cells cultured in vitro. Hence, we compared the morphology and function of rat ZG cells grown on plastic and Matrigel basement membrane matrix (hereinafter...

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PMID: 16685422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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