Article

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers of antidepressant response

2026-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Major depressive disorders (MDD) are predicted to become the first cause of burden of disease worldwide in 2030, but 30% of patients still do not respond to antidepressants. Current rodent models of MDD mainly result either from one genetic or one environmental risk factor exposure, not recapitulating the multifactorial and polygenic nature of MDD. We recently generated a polygenic mouse model o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66129471-4808-58e8-9743-e963612edfce
DOI: 10.64898/2026.03.31.715499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers of antidepressant responseDOI 10.64898/2026.03.31.715499Read

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers predictive of treatment responseSemantic proximity Read

Identification of multiple genetic loci in the mouse controlling immobility time in the tail suspension and forced swimming tests.Semantic proximity Read

Translating the evidence for gene association with depression into mouse models of depression-relevant behaviour: current limitations and future potential.Semantic proximity Read

Genetic dissection of the tail suspension test: a mouse model of stress vulnerability and antidepressant response.Semantic proximity Read

Translational Identification of Transcriptional Signatures of Major Depression and Antidepressant ResponseSemantic proximity Read

Genetics and genomics of depression.Semantic proximity Read

Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-Like BehavioursSemantic proximity Read

The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorderSemantic proximity Read

Gender variation in whole genome sequencing of susceptibility genes in a rat model of depressionSemantic proximity Read

Individual differences in the chronic stress-induced depression-like behavior are mediated by the expression of Kcnj2 gene in the lateral septumSemantic proximity Read

Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion.Semantic proximity Read

Antidepressants and the resilience to early-life stress in inbred mouse strains.Semantic proximity Read