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Article

Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Aug 2006

Jennings Katie A, Loder Merewyn K, Sheward W John, Pei Qi, Deacon Robert M J, Benson Matthew A, Olverman Henry J, Hastie Nicholas D, Harmar Anthony J, Shen Sanbing, Sharp Trevor

Abstract excerpt

A commonly occurring polymorphic variant of the human 5-hydroxytryptamine (5-HT) transporter (5-HTT) gene that increases 5-HTT expression has been associated with reduced anxiety levels in human volunteer and patient populations. However, it is not known whether this linkage between genotype and anxiety relates to variation in 5-HTT expression and consequent changes in 5-HT transmission. Here we test this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16943551
DOI: 10.1523/JNEUROSCI.5356-05.2006
PMCID: PMC6675351

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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