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Article

Characterization of serotonin neurotransmission in knockout mice: implications for major depression.

Reviews in the neurosciences - 1 Jan 2012

Domínguez-López Sergio, Howell Rebecca, Gobbi Gabriella

Abstract excerpt

The interaction between genes and environment plays a significant role in the pathogenesis of major depression and mood disorders. Preclinical and clinical studies have established that a dysfunction of serotonin (5-HT) neurotransmission is a common hallmark in major depression and drugs acting on the 5-HT system have antidepressant properties. In the past 15 years, the development of knockout mice showing a...

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PMID: 23089640
DOI: 10.1515/revneuro-2012-0044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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