Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 5-HT(1A) receptor knockout mouse and anxiety.

Behavioural pharmacology - 1 Nov 2001

Olivier B, Pattij T, Wood S J, Oosting R, Sarnyai Z, Toth M

Abstract excerpt

The 5-HT(1A) receptor has been implicated in the modulation of anxiety processes, mainly via pharmacological experiments. The recent production, in three independent research groups, of 5-HT(1A) receptor knockout (R KO) mice in three different genetic backgrounds (C57BL/6J, 129/Sv, Swiss-Webster) led to the intriguing finding that all mice, independent from the genetic background strain from which the null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Arousal
Share to Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Nerve Net

Share to Receptors, Serotonin

Share to Social Environment

Source

Identifiers

PMID: 11742137
DOI: 10.1097/00008877-200111000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 5-HT(1A) receptor knockout mouse and anxiety.PMID 11742137Read ↗

5-HT1A receptor and 5-HT1B receptor knockout mice in stress and anxiety paradigms.Semantic proximity Read ↗

Increased anxiety of mice lacking the serotonin1A receptor.Semantic proximity Read ↗

Is this mouse anxious? The difficulties of interpreting the effects of genetic action. Commentary on Belzung "The genetic basis of the pharmacological effects of anxiolytics" and Olivier et al. "The 5-HT(1A) receptor knockout mouse and anxiety".Semantic proximity Read ↗

The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.Semantic proximity Read ↗

Mouse anxiety: the power of knockout.Semantic proximity Read ↗

Targeted gene mutation approaches to the study of anxiety-like behavior in mice.Semantic proximity Read ↗

Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion.Semantic proximity Read ↗

Anxious genes, emerging themes. Commentary on Belzung "The genetic basis of the pharmacological effects of anxiolytics" and Olivier et al. "The 5-HT(1A) receptor knockout mouse and anxiety".Semantic proximity Read ↗

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.Semantic proximity Read ↗

[The characteristics of the functional activity of the brain serotoninergic system in the manifestation of natural and pathological anxiety in mice: the effect of the genotype].Semantic proximity Read ↗

Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal.Semantic proximity Read ↗

Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.