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Article

Cortactin as a target for FAK in the regulation of focal adhesion dynamics.

PloS one - 1 Jan 2012

Tomar Alok, Lawson Christine, Ghassemian Majid, Schlaepfer David D

Abstract excerpt

BACKGROUND: Efficient cell movement requires the dynamic regulation of focal adhesion (FA) formation and turnover. FAs are integrin-associated sites of cell attachment and establish linkages to the cellular actin cytoskeleton. Cells without focal adhesion kinase (FAK), an integrin-activated tyrosine kinase, exhibit defects in FA turnover and cell motility. Cortactin is an actin binding adaptor protein that can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

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Source

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Identifiers

PMID: 22952866
DOI: 10.1371/journal.pone.0044041
PMCID: PMC3430618

Genes

PRR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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