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Article

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.

Journal of cell science - 1 Aug 1999

Sieg D J, Hauck C R, Schlaepfer D D

Abstract excerpt

FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events. FAK-null (FAK-) fibroblasts exhibit a rounded morphology, defects in cell migration, and an elevated number of cell-substratum contact sites. Here we show that stable re-expression of epitope-tagged FAK reversed the morphological defects of the FAK- cells through the dynamic regulation of actin...

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Identifiers

PMID: 10413676
DOI: 10.1242/jcs.112.16.2677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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