Article
Rac1-dependent actin filament organization in growth cones is necessary for beta1-integrin-mediated advance but not for growth on poly-D-lysine.
Journal of neurobiology - 1 Dec 1998
Kuhn T B, Brown M D, Bamburg J R
Abstract excerpt
The activity of filopodia and lamellipodia determines the advance, motility, adhesion, and sensory capacity of neuronal growth cones. The shape and dynamics of these highly motile structures originate from the continuous reorganization of the actin cytoskeleton in response to extracellular signal...
Topics
- Actins
- Animals
- Cell Differentiation
- Cell Size
- Cells, Cultured
- Chick Embryo
- Extracellular Matrix
- Fibronectins
- GTP-Binding Proteins
- Growth Cones
- Guanosine Triphosphate
- Immunohistochemistry
- Integrin beta1
- Laminin
- Motor Neurons
- Mutation
- Neurites
- Polylysine