Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study.

doi:10.1002/ajmg.b.32068

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Article

Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2012

Xie Pingxing, Kranzler Henry R, Farrer Lindsay, Gelernter Joel

Abstract excerpt

We reported that the 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) moderates the effect of childhood adversity on posttraumatic stress disorder (PTSD) risk [Xie et al. (2009); Arch Gen Psychiatry 66 (11): 1201-1209]. In the present study, we considered 5,178 subjects (a group with generally high substance dependence comorbidity, as for our previous study) using similar...

Topics

Adolescent
Adult
Black or African American
Child
Demography
Female
Genetic Predisposition to Disease
Humans
Logistic Models
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reproducibility of Results

Risk Factors

Serotonin Plasma Membrane Transport Proteins

Statistics as Topic

Stress Disorders, Post-Traumatic

Stress, Psychological

White People

Source

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Identifiers

PMID: 22693124
DOI: 10.1002/ajmg.b.32068
PMCID: PMC3428016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22693124-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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