Article
Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project.
The pharmacogenomics journal - 1 Apr 2011
Keers R, Uher R, Huezo-Diaz P, Smith R, Jaffee S, Rietschel M, Henigsberg N, Kozel D, Mors O, Maier W, Zobel A, Hauser J, Souery D, Placentino A, Larsen E R, Dmitrzak-Weglarz M, Gupta B, Hoda F, Craig I, McGuffin P, Farmer A E, Aitchison K J
Abstract excerpt
There is substantial inter-individual variation in response to antidepressants, and genetic variation may, in part, explain these differences. For example, there is evidence to suggest that variation in the serotonin transporter gene (SLC6A4) predicts response to selective serotonin reuptake inhibitors (SSRIs). Environmental factors such as the occurrence of stressful life events before treatment may also be...
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