Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TCRBV20S1 polymorphism does not influence the susceptibility to type 1 diabetes and multiple sclerosis in the Sardinian population.

Immunogenetics - 1 Feb 2012

Fozza Claudio, Zoledzieska Magdalena, Pitzalis Maristella, Simula Maria Pina, Galleu Antonio, Contini Salvatore, Bonfigli Silvana, Cucca Francesco, Longinotti Maurizio

Abstract excerpt

Among the different T-cell receptor (TCR) BV20S1 polymorphisms, nucleotide substitution at position 524 results in the introduction of a stop codon, whose potential functional relevance is still unknown. We have recently showed in Sardinian subjects the most elevated allele frequency ever reported worldwide for this "null allele" (0.44). As this variant generates a gap in the TCR repertoire, this preliminary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 1
Share to Founder Effect

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Multiple Sclerosis

Share to Polymorphism, Genetic

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 21927869
DOI: 10.1007/s00251-011-0575-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

TCRBV20S1 polymorphism does not influence the susceptibility to type 1 diabetes and multiple sclerosis in the Sardinian population.PMID 21927869Read ↗

High frequency of the TCRBV20S1 null allele in the Sardinian population.Semantic proximity Read ↗

TCRBV20S1 allele frequencies vary among human populations.Semantic proximity Read ↗

DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population.Semantic proximity Read ↗

The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone.Semantic proximity Read ↗

Lack of evidence for a role of the myelin basic protein gene in multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

TCRBV20S1 and TCRBV3S1 gene segment polymorphisms in systemic sclerosis.Semantic proximity Read ↗

The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.Semantic proximity Read ↗

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

T-cell receptor BV gene segment polymorphisms in healthy elderly individuals from the south of Brazil.Semantic proximity Read ↗

Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese.Semantic proximity Read ↗

Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.