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Article

The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.

International journal of immunogenetics - 1 Jun 2009

Lemos M C, Coutinho E, Gomes L, Bastos M, Fagulha A, Barros L, Carrilho F, Geraldes E, Regateiro F J, Carvalheiro M

Abstract excerpt

CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly as...

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Source

Identifiers

PMID: 19490216
DOI: 10.1111/j.1744-313X.2009.00844.x

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19490216-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.PMID 19490216Read ↗

Association between the CTLA-4 +49A/G polymorphism and type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design.Semantic proximity Read ↗

CTLA-4 +49 A/G polymorphism is associated with predisposition to type 1 diabetes in Iranians.Semantic proximity Read ↗

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CTLA-4 (+49A/G) polymorphism and type-1 diabetes in Turkish children.Semantic proximity Read ↗

Common variants on cytotoxic T lymphocyte antigen-4 polymorphisms contributes to type 1 diabetes susceptibility: evidence based on 58 studies.Semantic proximity Read ↗

CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis.Semantic proximity Read ↗

CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function.Semantic proximity Read ↗

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CTLA-4 (+49A/G) Polymorphism in Type 1 Diabetes Children of Sudanese PopulationSemantic proximity Read ↗

Association of CTLA-4 (+49A/G) gene polymorphism with type 1 diabetes mellitus in Egyptian children.Semantic proximity Read ↗

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