Article
TCRBV20S1 and TCRBV3S1 gene segment polymorphisms in systemic sclerosis.
The Journal of rheumatology - 1 Jun 2008
Bredemeier Markus, Chies José Artur Bogo, Wieck Andréa, Capobianco Karina Gatz, Pitrez Eduardo Hennemann, Rohde Luis Eduardo Paim, Pinotti Antônio Fernando Furlan, Brenol João Carlos Tavares, Xavier Ricardo Machado
Abstract excerpt
OBJECTIVE: To compare the frequencies of variants of TCRBV20S1 and TCRBV3S1 gene segments in patients with systemic sclerosis (SSc) and in controls. The null allele (allele 2) of TCRBV20S1 is associated with reduced levels of Vbeta20+ T-cells in the peripheral blood, while allele 1 of TCRBV3S1 is related to a low frequency of Vbeta3.1+ T-cells. METHODS: One hundred thirty patients with SSc and 118 healthy...
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