Article
Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians.
Rejuvenation research - 1 Jan 2006
Scola Letizia, Lio Domenico, Crivello Antonio, Candore Giuseppina, Forte Giusi Irma, Colonna-Romano Giuseppina, Pes Mario Giovanni, Carru Ciriaco, Ferrucci Luigi, Deiana Luca, Baggio Giovannella, Franceschi Claudio, Caruso Calogero
Abstract excerpt
Human leukocyte antigen (HLA) alleles, regulating type and intensity of the immune response, might influence life expectancy. In previous case-control studies the authors have demonstrated that both HLA-DR and -DQ alleles are not associated with longevity in the Sardinian population. On the other hand, association studies are subjected (as part of the homogeneity of the population in terms of geographic origin)...
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