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Article

The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone.

Human molecular genetics - 1 Dec 2004

Marrosu Maria Giovanna, Motzo Costantino, Murru Raffaele, Lampis Rosanna, Costa Gianna, Zavattari Patrizia, Contu Daniela, Fadda Elisabetta, Cocco Eleonora, Cucca Francesco

Abstract excerpt

Type 1 diabetes (T1D) and multiple sclerosis (MS) are two autoimmune diseases which exhibit a considerably higher incidence in Sardinia compared with the surrounding southern European populations. Surprisingly, a 5-fold increased prevalence of T1D has also been observed in Sardinian MS patients. Susceptibility to both disorders is associated with common variants of the HLA-DRB1 and -DQB1 loci. In this study, we...

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PMID: 15471889
DOI: 10.1093/hmg/ddh319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone.PMID 15471889Read ↗

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Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia.Semantic proximity Read ↗

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