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Article

The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers.

Pharmacogenetics and genomics - 1 Sept 2006

Oertel Bruno G, Schmidt Ronald, Schneider Andreas, Geisslinger Gerd, Lötsch Jörn

Abstract excerpt

AIM: To investigate whether OPRM1 118A>G polymorphism affects analgesic and respiratory depressive effects of alfentanil and assess its role for the therapeutic range of alfentanil. METHODS: In an open-label, single-occasion design, 10 non-carriers, four heterozygous and six homozygous carriers of the variant OPRM1 118G allele received a computerized infusion of alfentanil to achieve target effect-site...

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Source

Identifiers

PMID: 16906017
DOI: 10.1097/01.fpc.0000220566.90466.a2

Genes

OPRM1

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