Article
TCR-dependent transformation of mature memory phenotype T cells in mice.
The Journal of clinical investigation - 1 Oct 2011
Wang Xi, Werneck Miriam B F, Wilson Boris G, Kim Hye-Jung, Kluk Michael J, Thom Christopher S, Wischhusen Jonathan W, Evans Julia A, Jesneck Jonathan L, Nguyen Phuong, Sansam Courtney G, Cantor Harvey, Roberts Charles W M
Abstract excerpt
A fundamental goal in cancer research is the identification of the cell types and signaling pathways capable of initiating and sustaining tumor growth, as this has the potential to reveal therapeutic targets. Stem and progenitor cells have been implicated in the genesis of select lymphoid malignancies. However, the identity of the cells in which mature lymphoid neoplasms are initiated remains unclear. Here, we...
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