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A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients

28 Jul 2009

Abstract excerpt

Histologic transformation (HT) of follicular lymphoma to diffuse large B-cell lymphoma (DLBCL-t) is associated with accelerated disease course and drastically worse outcome, yet the underlying mechanisms are poorly understood. We show that a network of gene transcriptional modules underlies HT. Central to the network hierarchy is a signature strikingly enriched for pluripotency-related genes. These genes are...

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PMID: 19636063
DOI: 10.1182/blood-2009-02-202465

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