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Article

Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes.

Blood - 16 Dec 2021

Tonc Elena, Takeuchi Yoshiko, Chou Chun, Xia Yu, Holmgren Melanie, Fujii Chika, Raju Saravanan, Chang Gue Su, Iwamoto Masahiro, Egawa Takeshi

Abstract excerpt

The proliferative burst of B lymphocytes is essential for antigen receptor repertoire diversification during the development and selective expansion of antigen-specific clones during immune responses. High proliferative activity inevitably promotes oncogenesis, the risk of which is further elevated in B lymphocytes by endogenous gene rearrangement and somatic mutations. However, B-cell-derived cancers are rare,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Share to Proto-Oncogene Proteins c-myc

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Source

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Identifiers

PMID: 34283887
DOI: 10.1182/blood.2021011711
PMCID: PMC8678995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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