Article
Age-associated clonal B cells drive B cell lymphoma in mice.
Nature aging - 1 Oct 2024
Castro José P, Shindyapina Anastasia V, Barbieri Alessandro, Ying Kejun, Strelkova Olga S, Paulo João A, Tyshkovskiy Alexander, Meinl Rico, Kerepesi Csaba, Petrashen Anna P, Mariotti Marco, Meer Margarita V, Hu Yan, Karamyshev Alexander, Losyev Grigoriy, Galhardo Mafalda, Logarinho Elsa, Indzhykulian Artur A, Gygi Steven P, Sedivy John M, Manis John P, Gladyshev Vadim N
Abstract excerpt
Although cancer is an age-related disease, how the processes of aging contribute to cancer progression is not well understood. In this study, we uncovered how mouse B cell lymphoma develops as a consequence of a naturally aged system. We show here that this malignancy is associated with an age-associated clonal B cell (ACBC) population that likely originates from age-associated B cells. Driven by c-Myc...
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