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Article

Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.

Oncotarget - 6 Oct 2015

Wang Zhengqi, Medrzycki Magdalena, Bunting Silvia T, Bunting Kevin D

Abstract excerpt

Despite being an attractive molecular target for both lymphoid and myeloid leukemias characterized by activated tyrosine kinases, the molecular and physiological consequences of reduced signal transducer and activator of transcription-5 (Stat5) during leukemogenesis are not well known. Stat5 is a critical regulator of mouse hematopoietic stem cell (HSC) self-renewal and is essential for normal lymphocyte...

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Share to Bone Marrow Transplantation
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Leukemia, B-Cell

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to STAT5 Transcription Factor

Source

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Identifiers

PMID: 26338970
DOI: 10.18632/oncotarget.5009
PMCID: PMC4745704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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