Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis.

doi:10.1136/annrheumdis-2011-200275

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Article

Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis.

Annals of the rheumatic diseases - 1 Jan 2012

Carmona F David, Gutala Ramana, Simeón Carmen P, Carreira Patricia, Ortego-Centeno Norberto, Vicente-Rabaneda Esther, García-Hernández Francisco J, García de la Peña Paloma, Fernández-Castro Mónica, Martínez-Estupiñán Lina, Egurbide María Victoria, Tsao Betty P, Gourh Pravitt, Agarwal Sandeep K, Assassi Shervin, Mayes Maureen D, Arnett Frank C, Tan Filemon K, Martín Javier

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are related chronic autoimmune diseases of complex aetiology in which the interferon (IFN) pathway plays a key role. Recent studies have reported an association between IRF7 and SLE which confers a risk to autoantibody production. A study was undertaken to investigate whether the IRF7 genomic region is also involved in susceptibility to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21926187
DOI: 10.1136/annrheumdis-2011-200275
PMCID: PMC3369428

Genes

CDHR5
PHRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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