Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis.

doi:10.3899/jrheum.111270

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Article

Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis.

The Journal of rheumatology - 1 May 2012

Coustet Baptiste, Bouaziz Matthieu, Dieudé Philippe, Guedj Mickael, Bossini-Castillo Lara, Agarwal Sandeep, Radstake Timothy, Martin Javier, Gourh Pravitt, Elhai Muriel, Koumakis Eugénie, Avouac Jérôme, Ruiz Barbara, Mayes Maureen, Arnett Frank, Hachulla Eric, Diot Elisabeth, Cracowski Jean-Luc, Tiev Kiet, Sibilia Jean, Mouthon Luc, Frances Camille, Amoura Zahir, Carpentier Patrick, Cosnes Anne, Meyer Olivier, Kahan André, Boileau Catherine, Chiocchia Gilles, Allanore Yannick

Abstract excerpt

OBJECTIVE: Independent replication with large cohorts and metaanalysis of genetic associations are necessary to validate genetic susceptibility factors. The known tumor necrosis factor (ligand) superfamily, member 4 gene (TNFSF4) systemic lupus erythematosus (SLE) risk locus has been found to be associated with systemic sclerosis (SSc) in 2 studies, but with discrepancies between them for genotype-phenotype...

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Identifiers

PMID: 22422496
DOI: 10.3899/jrheum.111270
PMCID: PMC3687343

Genes

TNFSF4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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