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Article

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients.

Arthritis and rheumatism - 1 Feb 2010

Salloum Rafah, Franek Beverly S, Kariuki Silvia N, Rhee Lesley, Mikolaitis Rachel A, Jolly Meenakshi, Utset Tammy O, Niewold Timothy B

Abstract excerpt

OBJECTIVE: Interferon-alpha (IFNalpha) is a heritable risk factor for systemic lupus erythematosus (SLE). Genetic variation near IRF7 is implicated in SLE susceptibility. SLE-associated autoantibodies can stimulate IFNalpha production through the Toll-like receptor/IRF7 pathway. This study was undertaken to determine whether variants of IRF7 act as risk factors for SLE by increasing IFNalpha production and...

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Identifiers

PMID: 20112359
DOI: 10.1002/art.27182
PMCID: PMC2832192

Genes

PHRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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