Article
The interferon regulatory factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype.
Annals of the rheumatic diseases - 1 Jan 2011
Dawidowicz Karen, Allanore Yannick, Guedj Mickaël, Pierlot Céline, Bombardieri Stefano, Balsa Alejandro, Westhovens René, Barrera Pilar, Alves Helena, Teixeira Vitor Hugo, Petit-Teixeira Elisabeth, van de Putte Leo, van Riel Piet, Prum Bernard, Bardin Thomas, Meyer Olivier, Cornélis François, Dieudé Philippe
Abstract excerpt
BACKGROUND: Increased expression of type I IFN genes, also referred to as an IFN signature, has been detected in various autoimmune diseases including rheumatoid arthritis (RA). Interferon regulatory factors, such as IRF5, coordinate type I IFN expression. Multiple IRF5 variants were suggested as...
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