Article
Disease-driven detection of differential inherited SNP modules from SNP network.
Gene - 10 Dec 2011
Li Chuanxing, Li Yongsheng, Xu Juan, Lv Junying, Ma Ye, Shao Tingting, Gong Binsheng, Tan Renjie, Xiao Yun, Li Xia
Abstract excerpt
Detection of the synergetic effects between variants, such as single-nucleotide polymorphisms (SNPs), is crucial for understanding the genetic characters of complex diseases. Here, we proposed a two-step approach to detect differentially inherited SNP modules (synergetic SNP units) from a SNP network. First, SNP-SNP interactions are identified based on prior biological knowledge, such as their adjacency on the...
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