Article

Enriching human interactome with functional mutations to detect high-impact network modules underlying complex diseases

2019-09-30

Abstract excerpt

Progress in high-throughput -omics technologies moves us one step closer to the datacalypse in life sciences. In spite of the already generated volumes of data, our knowledge of the molecular mechanisms underlying complex genetic diseases remains limited. Increasing evidence shows that biological networks are essential, albeit not sufficient, for the better understanding of these mechanisms. The identification of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0c7c977-2de6-582a-9e6d-4c00b272962d
DOI: 10.1101/786798

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enriching human interactome with functional mutations to detect high-impact network modules underlying complex diseasesDOI 10.1101/786798Read

Enriching Human Interactome with Functional Mutations to Detect High-Impact Network Modules Underlying Complex Diseases.Semantic proximity Read

The Extent of Edgetic Perturbations in the Human Interactome Caused by Population-Specific Mutations.Semantic proximity Read

The Extent of Edgetic Perturbations in the Human Interactome Caused by Population-Specific MutationsSemantic proximity Read

Open Community Challenge Reveals Molecular Network Modules with Key Roles in DiseasesSemantic proximity Read

Towards prediction and prioritization of disease genes by the modularity of human phenome-genome assembled network.Semantic proximity Read

Assessment of network module identification across complex diseases.Semantic proximity Read

Inferring and Evaluating Network Medicine-Based Disease Modules with NextflowSemantic proximity Read

State of the Interactomes: an evaluation of molecular networks for generating biological insightsSemantic proximity Read

Multilayer view of pathogenic SNVs in human interactome through <i>in-silico</i> edgetic profilingSemantic proximity Read

Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases.Semantic proximity Read

dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks.Semantic proximity Read

Multilayer View of Pathogenic SNVs in Human Interactome through In Silico Edgetic Profiling.Semantic proximity Read