Article
Quantitative mapping of genetic similarity in human heritable diseases by shared mutations.
Human mutation - 1 Feb 2018
Zhao Huiying, Yang Yuedong, Lu Yutong, Mort Matthew, Cooper David N, Zuo Zhiyi, Zhou Yaoqi
Abstract excerpt
Many genetic diseases exhibit considerable epidemiological comorbidity and common symptoms, which provokes debate about the extent of their etiological overlap. The rapid growth in the number of known disease-causing mutations in the Human Gene Mutation Database (HGMD) has allowed us to characterize genetic similarities between diseases by ascertaining the extent to which identical genetic mutations are shared...
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