Article
Towards prediction and prioritization of disease genes by the modularity of human phenome-genome assembled network.
Journal of integrative bioinformatics - 22 Nov 2010
Jiang Jeffrey Q, Dress Andreas W M, Chen Ming
Abstract excerpt
Empirical clinical studies on the human interactome and phenome not only illustrates prevalent phenotypic overlap and genetic overlap between diseases, but also reveals a modular organization of the genetic landscape of human disease, providing new opportunities to reduce the complexity in dissecting the phenotype-genotype association. We here introduce a network-module based method towards phenotype-genotype...
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