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Article

Reactivity of alpha 1-antitrypsin mutants against proteolytic enzymes of the kallikrein-kinin, complement, and fibrinolytic systems.

The Journal of biological chemistry - 25 Jun 1990

Patston P A, Roodi N, Schifferli J A, Bischoff R, Courtney M, Schapira M

Abstract excerpt

Increased extracellular proteolysis because of unregulated activation of blood coagulation, complement, and fibrinolysis is observed in thrombosis, shock, and inflammation. In the present study, we have examined whether the plasma kallikrein-kinin system, the classical pathway of complement, and the fibrinolytic system could be inhibited by alpha 1-antitrypsin reactive site mutants. Wild-type alpha 1-antitrypsin...

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Identifiers

PMID: 2191958

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