Article
Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway.
The Journal of biological chemistry - 29 Mar 2013
Megyeri Márton, Harmat Veronika, Major Balázs, Végh Ádám, Balczer Júlia, Héja Dávid, Szilágyi Katalin, Datz Dániel, Pál Gábor, Závodszky Péter, Gál Péter, Dobó József
Abstract excerpt
Mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, have been thought to autoactivate when MBL/ficolin·MASP complexes bind to pathogens triggering the complement lectin pathway. Autoactivation of MASPs occurs in two steps: 1) zymogen autoactivation, when one proenzyme cleaves another proenzyme molecule of the same protease, and 2) autocatalytic activation, when the activated protease...
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