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Article

Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358.

The Journal of biological chemistry - 5 Feb 1990

Heeb M J, Bischoff R, Courtney M, Griffin J H

Abstract excerpt

alpha 1-Antitrypsin (alpha 1-AT) was recently identified as a major physiologic plasma inhibitor of activated protein C. The reaction with activated protein C of recombinant alpha 1-AT containing amino acid substitutions at the reactive center was studied. The substitution of Arg358 for Met, as o...

Topics

Arginine
Electrophoresis, Polyacrylamide Gel
Enzyme Activation
Genetic Variation
Humans
Kinetics
Leucine
Methionine
Protein C
Recombinant Proteins
alpha 1-Antitrypsin

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PMID: 2298753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2298753-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358.PMID 2298753Read ↗

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