Article
COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization.
The Journal of biological chemistry - 10 Feb 1995
Eldering E, Verpy E, Roem D, Meo T, Tosi M
Abstract excerpt
The region COOH-terminal to the reactive center loop is highly conserved in the serine protease inhibitor (serpin) family. We have studied the structural consequences of three substitutions (Val451-->Met, Phe455-->Ser, and Pro476-->Ser) found in this region of C1 inhibitor in patients suffering f...
Topics
- Angioedema
- Animals
- Antibodies, Monoclonal
- Carboxylic Acids
- Cell Line
- Chromatography, Gel
- Cross Reactions
- Electrophoresis, Polyacrylamide Gel
- Hot Temperature
- Humans
- Hydrolysis
- Mutation
- Precipitin Tests
- Serpins
- Trypsin