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Article

α1 -antitrypsin Pittsburgh and plasmin-mediated proteolysis.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2016

Henneuse A, Suchon P, Chambost H, Morange P E, Frere C, Alessi M C

Abstract excerpt

Essentials Patients with α-1-antitrypsin (α1-AT) Pittsburgh exhibit a mild bleeding tendency. A new case of α1-AT Pittsburgh with suspected high antifibrinolytic potential was studied. We showed that α1-AT Pittsburgh inhibits tissue plasminogen activator and plasmin. The antifibrinolytic potential of the variant contributes to explaining the mild bleeding phenotype. SUMMARY: α1 -Antitrypsin (α1 -AT) Pittsburgh...

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Source

Identifiers

PMID: 27468101
DOI: 10.1111/jth.13426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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