Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils.

doi:10.1172/JCI116260

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Article

Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils.

The Journal of clinical investigation - 1 Mar 1993

Eldering E, Huijbregts C C, Nuijens J H, Verhoeven A J, Hack C E

Abstract excerpt

Proteolytic inactivation of serine protease inhibitors (serpins) by neutrophil elastase (HNE) is presumed to contribute to the deregulation of plasma cascade systems in septic shock. Here, we report a supplementary approach to construct serpins, in our case C1 inhibitor, that are resistant to cat...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Clone Cells
Complement C1 Inactivator Proteins
Factor XIIa
Fibrinolysin
Genetic Variation
Humans
Kallikreins
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocyte Elastase

Molecular Sequence Data

Mutagenesis, Site-Directed

Neutrophils

Oligodeoxyribonucleotides

Pancreatic Elastase

Source

Open in PubMed Open full text

Identifiers

PMID: 8450033
DOI: 10.1172/JCI116260
PMCID: PMC288057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8450033-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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