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Article

Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils.

The Journal of clinical investigation - 1 Mar 1993

Eldering E, Huijbregts C C, Nuijens J H, Verhoeven A J, Hack C E

Abstract excerpt

Proteolytic inactivation of serine protease inhibitors (serpins) by neutrophil elastase (HNE) is presumed to contribute to the deregulation of plasma cascade systems in septic shock. Here, we report a supplementary approach to construct serpins, in our case C1 inhibitor, that are resistant to catalytic inactivation by HNE. Instead of shifting the specificity of alpha 1-antitrypsin towards the proteases of the...

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Identifiers

PMID: 8450033
DOI: 10.1172/JCI116260
PMCID: PMC288057

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