Article
Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.
Journal of virology - 1 Dec 2011
Jacobs J G, Bossers A, Rezaei H, van Keulen L J M, McCutcheon S, Sklaviadis T, Lantier I, Berthon P, Lantier F, van Zijderveld F G, Langeveld J P M
Abstract excerpt
Classical scrapie is a prion disease in sheep and goats. In sheep, susceptibility to disease is genetically influenced by single amino acid substitutions. Genetic breeding programs aimed at enrichment of arginine-171 (171R) prion protein (PrP), the so-called ARR allele, in the sheep population have been demonstrated to be effective in reducing the occurrence of classical scrapie in the field. Understanding the...
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