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Article

Protective effect of the AT137RQ and ARQK176 PrP allele against classical scrapie in Sarda breed sheep.

Veterinary research - 1 Jan 2000

Vaccari Gabriele, Scavia Gaia, Sala Marcello, Cosseddu Gianmario, Chiappini Barbara, Conte Michela, Esposito Elena, Lorenzetti Raniero, Perfetti Gabriella, Marconi Paola, Scholl Francesco, Barbaro Katia, Bella Antonino, Nonno Romolo, Agrimi Umberto

Abstract excerpt

The susceptibility of sheep to scrapie is under the control of the host's prion protein (PrP gene and is also influenced by the strain of the agent. PrP polymorphisms at codons 136 (A/V), 15 (R/H) and 171 (Q/R/H) are the main determinants of susceptibility/resistance of sheep to classical scrapie. They are combined in four main variants of the wild-type ARQ allele: VRQ, AHQ, ARH and ARR. Breeding programmes have...

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Identifiers

PMID: 19171116
DOI: 10.1051/vetres/2009002
PMCID: PMC2695041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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